233 papers
Molecular biology explores the tiny machinery inside living cells, revealing how genetic instructions are read, copied, and turned into the proteins that keep us alive. This field acts as a bridge between the static code of DNA and the dynamic processes that drive growth, disease, and life itself, offering insights into everything from cellular repair to the development of new medicines.
On Gist.Science, we track every new preprint uploaded to bioRxiv in this category to make these complex discoveries accessible to everyone. Our team processes each submission to provide both clear, plain-language explanations and detailed technical summaries, ensuring you can grasp the core findings without getting lost in dense academic jargon.
Below are the latest molecular biology papers freshly processed from bioRxiv, ready for you to explore and understand.
This study demonstrates that the H2A.Z R80C mutant suppresses the senescence-associated secretory phenotype (SASP) in human fibroblasts by destabilizing nucleosomes to reduce H3K27ac levels at SASP gene loci, independent of cell cycle regulation or H2A.Z depletion.
This study introduces a Compound Heterozygous Allele Conversion Reporter (CHACR) cell line to elucidate the mechanisms of Cas9-mediated allele conversion, demonstrating that targeted DNA damage can repair heterozygous mutations using the homologous allele as a template and that this efficiency can be enhanced by modulating DNA repair pathways.
This manuscript, which originally investigated the role of estrogen in enhancing cardiac protection via extracellular vesicles from cardiac progenitor cells, has been withdrawn by the authors to incorporate additional data and undergo substantial revision prior to resubmission.
This study demonstrates that an allele-specific antisense oligonucleotide effectively clears mutant EFEMP1 transcripts and reverses disease-associated extracellular deposits and intracellular lipid accumulation in a patient-derived model of Doyne honeycomb retinal dystrophy, suggesting a promising therapeutic strategy for this incurable condition.
This paper introduces two training-free, inference-time conditioning strategies, Interpolate-Integrate and Replacement Guidance, for E(3)-equivariant flow-matching models to enable efficient, high-quality bioisosteric 3D ligand design without costly retraining.
This paper introduces HAMMER, a rapid, scalable, and specific luminescence-based cellular assay that quantifies APOBEC3A-mediated RNA editing activity by measuring the conversion of a CGA motif to a UGA stop codon, thereby enabling the characterization of both enzymatic activity and inhibitors.
This study reveals that the MRE11 protein suppresses germline mutagenesis in mice by preventing the error-prone end joining of closely spaced meiotic double-strand breaks, a process that otherwise leads to microdeletions and structural variants, particularly when ATM kinase signaling is compromised.
This study utilizes high-throughput sequencing to reveal a more complex Spanish citrus virome than previously known, identifying the first occurrences of citrus virus A and the T3 genotype of citrus tristeza virus alongside citrus yellow vein clearing virus, thereby highlighting the critical role of advanced surveillance in detecting emerging threats to the citrus industry.
The paper identifies the nucleoporin Nup42 as a key factor that prevents heat-induced chaperone mRNAs from undergoing nuclear condensation, thereby ensuring their solubility and efficient translation to support the cellular heat shock response.
By generating combinatorial mutants of various methyl reader proteins and silencing pathways, the study demonstrates that multiple redundant mechanisms work cooperatively to account for the majority of DNA methylation-mediated gene silencing and the maintenance of 3D genome organization.