316 papers
Molecular biology explores the tiny machinery inside living cells, revealing how genetic instructions are read, copied, and turned into the proteins that keep us alive. This field acts as a bridge between the static code of DNA and the dynamic processes that drive growth, disease, and life itself, offering insights into everything from cellular repair to the development of new medicines.
On Gist.Science, we track every new preprint uploaded to bioRxiv in this category to make these complex discoveries accessible to everyone. Our team processes each submission to provide both clear, plain-language explanations and detailed technical summaries, ensuring you can grasp the core findings without getting lost in dense academic jargon.
Below are the latest molecular biology papers freshly processed from bioRxiv, ready for you to explore and understand.
ProAR introduces a probabilistic autoregressive framework with a dual-network system and anti-drifting sampling strategy to generate flexible, long-length molecular dynamics trajectories that better capture time-dependent conformational diversity and reduce reconstruction errors compared to existing state-of-the-art methods.
This study reveals that ATM safeguards DNA replication by preventing aberrant PRIMPOL-dependent repriming at spontaneous oxidative base lesions, and its absence creates replication gaps that require homologous recombination for repair, thereby driving synthetic lethality with PARP inhibitors.
This study reveals that free-roaming dogs and diverse rodent species in rural Tha Wang Pha, Thailand, serve as reservoirs for multiple pathogenic *Leptospira* species, including the first confirmed detection of *L. weilii* in Thai rodents, highlighting a complex transmission cycle that bridges animal habitats and human settlements and underscores the need for integrated One Health surveillance.
This study demonstrates that while native codon sequences are generally sufficient for robust mammalian glycoprotein expression, a skewed codon strategy utilizing the most abundant codons can occasionally enhance yields, all evaluated using a newly developed open-source Golden Gate compatible vector called pTipi.
This study utilizes single-cell RNA sequencing to characterize the cellular heterogeneity of the ISE6 tick cell line and reveals that Ehrlichia muris eauclairensis infection induces time-dependent transcriptional shifts, initially upregulating stress and metabolic pathways before downregulating cell cycle and cytoskeletal genes, thereby confirming the cell line's utility for studying tick-pathogen interactions.
This study identifies 5,945 tissue-conserved m6A sites across 24 human tissues that are mediated by RBM15/B and linked to mRNA decay, revealing a stable epitranscriptomic layer regulating essential genes whose disruption is associated with transcriptional dysregulation in cancer.
Despite previous reports linking TTC22 to colon adenocarcinoma metastasis in humans, this study demonstrates that CRISPR-Cas9-mediated inactivation of the Ttc22 gene in C57BL/6N mice results in no observable phenotypic abnormalities, including normal development, fertility, and tumor incidence.
This study demonstrates that combining the alpha-synuclein aggregation inhibitor anle138b with the ER stress inhibitor AMG PERK 44 significantly enhances neuroprotection in a Parkinson's disease organoid model by improving metabolic activity, reducing alpha-synuclein pathology and cell death, and restoring proteostasis.
This study demonstrates that the cardiomyocyte-enriched protein FYCO1 mitigates post-ischemic cardiac remodeling and preserves heart function by enhancing autophagic flux and suppressing pro-inflammatory signaling following myocardial infarction.
This study reveals a positive feedback loop in which GABARAP, a member of the mATG8 family, directly binds to and activates the PtdIns3K-C1 complex to boost PtdIns3P production, thereby accelerating phagophore nucleation and enabling the rapid expansion of autophagosomes during starvation.